BDBM620916 (3S,4S) or (3R,4R) 4-(4-(6- chloro-2-((5-(difluoromethyl)-1- isopropyl-1H-pyrazol-4- yl)amino)quinazolin-7- yl)piperazin-1-yl)-4- methyltetrahydrofuran-3-ol::US20230303540, Example Ex-6.50

SMILES CC(C)n1ncc(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)c1C(F)F

InChI Key InChIKey=RJMDGRABWWOOKW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620916   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620916((3S,4S) or (3R,4R) 4-(4-(6- chloro-2-((5-(difluoro...)
Affinity DataIC50: 0.0800nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent