BDBM620919 (3S,4S) or (3R,4R) 4-(4-(7- chloro-3-((1-(2,2- difluorocyclopropyl)-5-methyl- 1H-pyrazol-4- yl)amino)isoquinolin-6- yl)piperazin-1-yl)-4- methyltetrahydrofuran-3-ol::US20230303540, Example Ex-6.53

SMILES Cc1c(Nc2cc3cc(N4CCN(CC4)C4(C)COCC4O)c(Cl)cc3cn2)cnn1C1CC1(F)F

InChI Key InChIKey=ZIMNJQWEXCPXEQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620919   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620919((3S,4S) or (3R,4R) 4-(4-(7- chloro-3-((1-(2,2- dif...)
Affinity DataIC50: 0.522nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent