BDBM620948 (1R,4S) or (1S,4R)-2-(2-((3- methyl-1-(2-(oxetan-3-yl)-2- azaspiro[3.3]heptan-6-yl)-1H- pyrazol-4-yl)amino)quinazolin- 7-yl)-2-azabicyclo[2.2.1]heptan- 3-one::US20230303540, Example Ex-8.5::US20230303540, Example Ex-8.6

SMILES Cc1nn(cc1Nc1ncc2ccc(cc2n1)N1C2CCC(C2)C1=O)C1CC2(C1)CN(C2)C1COC1

InChI Key InChIKey=MHLSTWJUILGVJD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620948   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620948(US20230303540, Example Ex-8.6 | (1R,4S) or (1S,4R)...)
Affinity DataIC50: 0.625nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620948(US20230303540, Example Ex-8.6 | (1R,4S) or (1S,4R)...)
Affinity DataIC50: 4.86nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent