BDBM621028 4-(benzothiazole-6-yl)-5-fluoro-N-(5-((4-isopropylpiperazine-1-yl)methyl)pyridine-2-yl)pyrimidine-2-amine::US20230303553, Example 11

SMILES CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3ccc4ncsc4c3)nc2)CC1

InChI Key InChIKey=MCHFBGTXGSLCLO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621028   

TargetCyclin-dependent kinase 6(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621028(US20230303553, Example 11 | 4-(benzothiazole-6-yl)...)
Affinity DataIC50: 175nMAssay Description:Table 1: In the test plate, protein kinase, Ulight-labeled polypeptide substrate, ATP, and the compounds were mixed and the reaction was incubated. E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Jiangsu Tasly Diyi Pharmaceutical

US Patent
LigandPNGBDBM621028(US20230303553, Example 11 | 4-(benzothiazole-6-yl)...)
Affinity DataIC50: 263nMAssay Description:The DYRK2 kinase inhibitory activity of the compounds of the invention were measured. The method was briefly described as follows (for specific metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent