BDBM621084 US20230303563, Compound 19

SMILES CC(C)(O)c1ccc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4F)n3)n2c1

InChI Key InChIKey=KPKVXBUKMZIGPN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 621084   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 0.600nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 0.600nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 117nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621084BDBM621084(US20230303563, Compound 19)
Affinity DataIC50: 140nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMed