BDBM621734 US20230312504, Compound 1

SMILES CCN1CCN(Cc2cc(F)c(NC(=O)Cc3ccc(nc3)-c3cnc4cc(OC)c(OC)cc4c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=ZZWZYEZSFZRFRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 621734   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:The inhibitory activity of the test compounds against human wild-type and V804M mutant RET kinase was evaluated by measuring IC50 values in a 33P-lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 0.900nMAssay Description:The inhibitory activity of the test compounds against human wild-type and V804M mutant RET kinase was evaluated by measuring IC50 values in a 33P-lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 0.900nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetCytochrome P450 2C9(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 1.25E+4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetCytochrome P450 2C19(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 1.69E+4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetCytochrome P450 2D6(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 1.88E+4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetCytochrome P450 1A2(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 5.00E+4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent

TargetCytochrome P450 3A4(Human)
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

US Patent
LigandChemical structure of BindingDB Monomer ID 621734BDBM621734(US20230312504, Compound 1 | US12565481, Compound 1)
Affinity DataIC50: 5.00E+4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2026
Entry Details US Patent