BDBM621853 (4S)-N-[(R or S)-(3- chloro-2,4-di- fluoro-phenyl)(3,3- dimethylcyclobutyl)meth- yl]-2- oxoimidazolidine-4- carboxamide::US20230312528, Example 30A

SMILES CC1(C)CC(C1)[C@H](NC(=O)[C@@H]1CNC(=O)N1)c1ccc(F)c(Cl)c1F

InChI Key InChIKey=SUTRAXOAVVBEAL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 621853   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621853(US20230312528, Example 30A | (4S)-N-[(R or S)-(3- ...)
Affinity DataIC50: 4.60nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent