BDBM621880 (S)-N-((R or S)-(5- fluoro-6-(2,2,2- trifluoroethoxy)pyridin- 3-yl)(5-fluoro-6- (trifluoromethyl)pyridin- 2-yl)methyl)-2- oxoimidazolidine-4- carboxamide::US11802122, Example 46B::US20230312528, Example 46B

SMILES Fc1ccc(nc1C(F)(F)F)C(NC(=O)[C@@H]1CNC(=O)N1)c1cnc(OCC(F)(F)F)c(F)c1

InChI Key InChIKey=NKBZLMWPWUWKIQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 621880   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621880(US20230312528, Example 46B | US11802122, Example 4...)
Affinity DataIC50: 6nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621880(US20230312528, Example 46B | US11802122, Example 4...)
Affinity DataIC50: 6nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621880(US20230312528, Example 46B | US11802122, Example 4...)
Affinity DataIC50: 27nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621880(US20230312528, Example 46B | US11802122, Example 4...)
Affinity DataIC50: 27nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent