BDBM622112 US20230312550, Example 72

SMILES C[C@@H]1CN(CCO1)c1ccc2nccc(C(=O)NCC(=O)N3CSC[C@H]3C#N)c2c1

InChI Key InChIKey=SYHFAICFDJDHOZ-UHFFFAOYSA-N

Data  5 IC50  1 Kd  1 Koff  1 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 622112   

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataKd:  0.0260nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using human Fibroblast activation protein alpha (hFAP) enzyme at 2.4 pM FAC (Protero...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataIC50: 0.0790nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataIC50: 1.90E+3nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 9(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataIC50: 2.50E+3nMAssay Description:Table 4: Compounds were tested in a biochemical inhibition assay using human dipeptidylpeptidase 9 (hDPP9) enzyme at 0.4 nM FAC (BPS Bioscience, #800...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 8(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataIC50: 6.60E+3nMAssay Description:Table 4: Compounds were tested in a biochemical inhibition assay using human dipeptidylpeptidase 8 (hDPP8) enzyme at 1.5 nM FAC (BPS Bioscience, #800...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetDipeptidyl peptidase 2(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataIC50: 1.00E+5nMAssay Description:Table 4: Compounds were tested in a biochemical inhibition assay using human dipeptidylpeptidase 7 (hDPP7) enzyme at 15 nM FAC (BPS Bioscience, #8007...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataKon:  0.000160M-1s-1Assay Description:Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622112(US20230312550, Example 72)
Affinity DataKoff:  5.20E+6s-1Assay Description:Table 1: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hFA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent