BDBM622179 US20230312550, Example 139

SMILES O=C(CNC(=O)c1ccnc2ccc(cc12)N1CC2(C1)CCCC2)N1CSC[C@H]1C#N

InChI Key InChIKey=YXBOJNLQVIBFOO-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622179   

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622179(US20230312550, Example 139)
Affinity DataKd:  0.0150nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using human Fibroblast activation protein alpha (hFAP) enzyme at 2.4 pM FAC (Protero...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetProlyl endopeptidase FAP(Human)
Astrazeneca

US Patent
LigandPNGBDBM622179(US20230312550, Example 139)
Affinity DataIC50: 0.320nMAssay Description:Table 1: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Human)
Astrazeneca

US Patent
LigandPNGBDBM622179(US20230312550, Example 139)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent