BDBM622277 4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (Compound 27) and 4-amino-N-(1-((4-chloro-2-fluorophenyl)(hydroxy)methyl)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide ::US20230312556, Compound 28

SMILES Cc1ccc2c(nccc2c1NC(=O)c1csc2c(N)ncnc12)C(O)c1ccc(Cl)cc1F

InChI Key InChIKey=VZRJWJRXUXNMFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622277   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622277(4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...)
Affinity DataIC50: 3.48nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622277(4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...)
Affinity DataIC50: 4.58nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622277(4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...)
Affinity DataIC50: 9.43nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent