BDBM622282 4-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)imidazo[2,1-f][1,2,4]triazine-7-carboxamide ::US20230312556, Compound 43

SMILES Cc1ccc2c(Nc3cccc(c3)C(F)(F)F)nccc2c1NC(=O)c1cnc2c(N)ncnn12

InChI Key InChIKey=VIZDRIJHAPAUMH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622282   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622282(4-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)...)
Affinity DataIC50: 4.49nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622282(4-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)...)
Affinity DataIC50: 4.84nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622282(4-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)...)
Affinity DataIC50: 20.7nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent