BDBM622288 4-amino-N-(1-((2,4-difluorophenyl)amino)-6-methylisoquinolin-5-yl)-6-fluoroquinazoline-8-carboxamide ::US20230312556, Compound 85

SMILES COc1ccc(CNc2ncnc3c(cc(F)cc23)C(=O)Nc2c(C)ccc3c(Nc4ccc(F)cc4F)nccc23)c(OC)c1

InChI Key InChIKey=ODJSSAIGXKSLMS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622288   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622288(4-amino-N-(1-((2,4-difluorophenyl)amino)-6-methyli...)
Affinity DataIC50: 4.43nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622288(4-amino-N-(1-((2,4-difluorophenyl)amino)-6-methyli...)
Affinity DataIC50: 9.02nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622288(4-amino-N-(1-((2,4-difluorophenyl)amino)-6-methyli...)
Affinity DataIC50: 12.9nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent