BDBM622291 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-fluoroisoquinolin-5-yl)quinazoline-8-carboxamide ::US20230312556, Compound 92

SMILES COc1ccc(CNc2ncnc3c(cccc23)C(=O)Nc2c(F)ccc3c(Nc4cccc(Cl)c4F)nccc23)c(OC)c1

InChI Key InChIKey=CVPQAGYSQPJNCU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 622291   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622291(4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-fl...)
Affinity DataIC50: 5.34nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622291(4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-fl...)
Affinity DataIC50: 10.8nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622291(4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-fl...)
Affinity DataIC50: 21.8nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent