BDBM622306 4-amino-N-(1-(3-chlorobenzyl)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide ::US20230312556, Compound 16

SMILES COc1ccc(CNc2ncnc3c(csc23)C(=O)Nc2c(C)ccc3c(Cc4cccc(Cl)c4)nccc23)c(OC)c1

InChI Key InChIKey=URMUPVWARDGOPJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622306   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622306(4-amino-N-(1-(3-chlorobenzyl)-6-methylisoquinolin-...)
Affinity DataIC50: 6.27nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent