BDBM622311 4-amino-N-(1-((2-chlorophenyl)(hydroxy)methyl)-6-methylisoquinolin-5-yl)quinazoline-8-carboxamide ::US20230312556, Compound 24

SMILES Cc1ccc2c(nccc2c1NC(=O)c1cccc2c(N)ncnc12)C(O)c1ccccc1Cl

InChI Key InChIKey=BNDSMKCAXONIBH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622311   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622311(4-amino-N-(1-((2-chlorophenyl)(hydroxy)methyl)-6-m...)
Affinity DataIC50: 7.10nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent