BDBM622312 4-amino-N-(1-(2-chlorobenzyl)-6-methylisoquinolin-5-yl)quinazoline-8-carboxamide ::US20230312556, Compound 25

SMILES COc1ccc(CNc2ncnc3c(cccc23)C(=O)Nc2c(C)ccc3c(Cc4ccccc4Cl)nccc23)c(OC)c1

InChI Key InChIKey=OEINNGSGSUELLK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622312   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622312(4-amino-N-(1-(2-chlorobenzyl)-6-methylisoquinolin-...)
Affinity DataIC50: 6.31nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent