BDBM622330 Preparation of 4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-methylisoquinolin-5-yl)imidazo[2,1-f][1,2,4]triazine-7-carboxamide ::US20230312556, Compound 61

SMILES COc1ccc(Nc2nccc3c(NC(=O)c4cnc5c(N)ncnn45)c(C)ccc23)c(F)c1

InChI Key InChIKey=OFBVFNBKXDQWQA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622330   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622330(Preparation of 4-amino-N-(1-((2-fluoro-4-methoxyph...)
Affinity DataIC50: 2.88nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent