BDBM622353 4-amino-N-(1-((2-fluoro-5-methoxyphenyl)amino)-6-methylisoquinolin-5-yl)quinazoline-8-carboxamide ::US20230312556, Compound 87

SMILES COc1ccc(F)c(Nc2nccc3c(NC(=O)c4cccc5c(NCc6ccc(OC)cc6OC)ncnc45)c(C)ccc23)c1

InChI Key InChIKey=BUAIUUGQFJRKDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622353   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622353(4-amino-N-(1-((2-fluoro-5-methoxyphenyl)amino)-6-m...)
Affinity DataIC50: 4.64nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent