BDBM622358 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide ::US20230312556, Compound 101

SMILES COc1ccc(CNc2ncnc3c(cn(C)c23)C(=O)Nc2c(C)ccc3c(Nc4cccc(Cl)c4F)nccc23)c(OC)c1

InChI Key InChIKey=VZHIZYITGWGMBW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 622358   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM622358(4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 5.58nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent