BDBM622574 US20230312601, Example 5

SMILES CO[C@H](C(F)F)c1c(Nc2ccc(cc2)[C@H](N(C)C(=O)C2CCS(=O)(=O)CC2)C(F)(F)F)cnc2sc(C)nc12

InChI Key InChIKey=PAYLSDXOSCGRBN-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 622574   

LigandPNGBDBM622574(US20230312601, Example 5)
Affinity DataEC50:  77nMAssay Description:Inhibition of human MALT-1 protease activity using TAMRA-PEG2-Leu-Val-Ser-Arg-Gly-Ala-Ala-Ser-PEG2-K(QSY7) preincubated for 40 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM622574(US20230312601, Example 5)
Affinity DataEC50:  77nMAssay Description:A Quenched Fluorescence Resonance Energy Transfer (Quench-FRET) enzyme assay was used to test the ability of exemplary MALT-1 inhibitors Example 1 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent