BDBM623324 US11780845, Example 1028::US11780845, Example 343
SMILES CC(=C)C(=O)Nc1ccc(cc1)-c1c(-c2ccc(Oc3nccc(C)n3)c(F)c2)c2c(N)ncnc2n1C
InChI Key InChIKey=XOQVZSSDIQQUGO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 623324
Affinity DataIC50: 0.120nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type FGFR2 (458 to 765 residues)(unknown origin) expressed in Escherichia coli using FLPeptide30 as substrate preincubated for 30 ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of FGFR2 K641R mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of FGFR2 E565G mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 120 mins followed by substrate addition in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of FGFR2 V564I mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 90 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of FGFR3 V555L mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 30 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were also tested in a FGFR2 Biochemical Caliper Assay. Compounds were prepared in 10 mM DMSO solution and serially...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were also tested in a FGFR2 Biochemical Caliper Assay. Compounds were prepared in 10 mM DMSO solution and serially...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 15 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 149nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 5 mins followed by substrate addition in presence of Km...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 201nMAssay Description:Inhibition of FGFR2 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 10 mins followed by substrate addition in presence of K...More data for this Ligand-Target Pair
Affinity DataIC50: 202nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataKi: 272nMAssay Description:Binding affinity to FGFR2 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 274nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 274nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 325nMAssay Description:Inhibition of FGFR3 K650E mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of FGFR3 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 446nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) using Fluorescein-poly GAT as substrate incubated for 60 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 864nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 864nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.45E+3nMAssay Description:Binding affinity to FGFR3 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) using fluorescein-Poly GAT as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair