BDBM623324 US11780845, Example 1028::US11780845, Example 343

SMILES CC(=C)C(=O)Nc1ccc(cc1)-c1c(-c2ccc(Oc3nccc(C)n3)c(F)c2)c2c(N)ncnc2n1C

InChI Key InChIKey=XOQVZSSDIQQUGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 623324   

TargetFibroblast growth factor receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild-type FGFR2 (458 to 765 residues)(unknown origin) expressed in Escherichia coli using FLPeptide30 as substrate preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were also tested in a FGFR2 Biochemical Caliper Assay. Compounds were prepared in 10 mM DMSO solution and serially...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 100nMAssay Description:Compounds of the present invention were also tested in a FGFR2 Biochemical Caliper Assay. Compounds were prepared in 10 mM DMSO solution and serially...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 274nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 864nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM623324(US11780845, Example 1028 | US11780845, Example 343)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed