BDBM624944 US20230322745, Compound 11

SMILES CN(CCCn1nnc2cc(CNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)c3cnn(C)c3c12)[C@H]1CC[C@@H](CC1)OC(=O)C(O)(c1cccs1)c1cccs1

InChI Key InChIKey=GJLQIWOFIGFHLI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 624944   

TargetMuscarinic acetylcholine receptor M3(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM624944(US20230322745, Compound 11)
Affinity DataIC50: 0.638nMAssay Description:The experiment was performed by a radioisotope affinity assay. The M3 receptor membrane protein was prepared at 10 μg/mL by Biology Department o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetBeta-2 adrenergic receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM624944(US20230322745, Compound 11)
Affinity DataEC50:  1.12nMAssay Description:β1 cells (expressing human ADRB1 gene) from ICE Bioscience Inc. were grown under standard conditions. The cells were collected and diluted with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent