BDBM625041 US20230322747, Compound 59::US20260102395, Compound 59

SMILES Cc1noc2cc(OCc3ccc(cn3)-c3nnc(o3)C(F)F)ccc12

InChI Key InChIKey=GHEYGXMQJSUUPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 625041   

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625041BDBM625041(US20230322747, Compound 59 | US20260102395, Compou...)
Affinity DataIC50: 50nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625041BDBM625041(US20230322747, Compound 59 | US20260102395, Compou...)
Affinity DataIC50: 50nMAssay Description:The biochemical HDAC6 assay was performed using fluorescence detection (Fluor-De-Lys assay). In this assay, deacetylation of the Lysine residue in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625041BDBM625041(US20230322747, Compound 59 | US20260102395, Compou...)
Affinity DataIC50: 1.00E+5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625041BDBM625041(US20230322747, Compound 59 | US20260102395, Compou...)
Affinity DataIC50: 1.00E+5nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent