BDBM625107 US20230322747, Compound 132::US20250250263, Compound 132::US20260102395, Compound 132

SMILES FC(F)c1nnc(o1)-c1cnc(COc2cccc3ncccc23)c(F)c1

InChI Key InChIKey=RNAHUPFESYEMLS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 625107   

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625107BDBM625107(US20230322747, Compound 132 | US20250250263, Compo...)
Affinity DataIC50: 50nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625107BDBM625107(US20230322747, Compound 132 | US20250250263, Compo...)
Affinity DataIC50: 50nMAssay Description:The biochemical HDAC6 assay was performed using fluorescence detection (Fluor-De-Lys assay). In this assay, deacetylation of the Lysine residue in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625107BDBM625107(US20230322747, Compound 132 | US20250250263, Compo...)
Affinity DataIC50: 50nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, if app...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2025
Entry Details
US Patent