BDBM625143 US20230322747, Compound 183::US20260102395, Compound 183

SMILES FC(F)c1nnc(o1)-c1ccc(COc2cnc3ccnn3c2)nc1

InChI Key InChIKey=ZVDZTHZYMZWJNN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 625143   

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625143BDBM625143(US20230322747, Compound 183 | US20260102395, Compo...)
Affinity DataIC50: 50nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2026
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Eikonizo Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 625143BDBM625143(US20230322747, Compound 183 | US20260102395, Compo...)
Affinity DataIC50: 50nMAssay Description:The biochemical HDAC6 assay was performed using fluorescence detection (Fluor-De-Lys assay). In this assay, deacetylation of the Lysine residue in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent