BDBM625352 US20230322769, Compound 65

SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CCOCC2)cn1

InChI Key InChIKey=JFYWOOJDLHFQAP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 625352   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  2.72E+3nMAssay Description:Inhibition of hERG Potassium Channel by Prepared Compounds The final concentrations of test compounds were all prepared on the day of experiment and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  1.09nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  92.8nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  0.920nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  0.520nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50:  3.37nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent