BDBM625366 US12583855, Example 7::US20230322769, Compound 86

SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)N2CC(C)(O)C2)cn1

InChI Key InChIKey=MVQAYSXDCGCOIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 625366   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 625366BDBM625366(US20230322769, Compound 86 | US12583855, Example 7)
Affinity DataIC50: 0.601nMAssay Description:Cytokinesis is a cell-based assay to assess nonmuscle myosin II function, performed using COS7 cells. The assay is run in a 96 well plate, with 2,000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 625366BDBM625366(US20230322769, Compound 86 | US12583855, Example 7)
Affinity DataIC50: 4.56nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 625366BDBM625366(US20230322769, Compound 86 | US12583855, Example 7)
Affinity DataIC50: 9.67nMAssay Description:Cytokinesis is a cell-based assay to assess nonmuscle myosin II function, performed using COS7 cells. The assay is run in a 96 well plate, with 2,000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 625366BDBM625366(US20230322769, Compound 86 | US12583855, Example 7)
Affinity DataIC50: 71.3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent