BDBM625401 US20230322788, Compound B5

SMILES CN1CCC[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C=C)c2[nH]cc(Cc3c(ccc4[nH]ncc34)C(F)(F)F)c2n1

InChI Key InChIKey=LQHAFOFPTKZALC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 625401   

TargetGTPase KRas [G12C,C51S,C80L,C118S](Human)
Beigene

US Patent
LigandPNGBDBM625401(US20230322788, Compound B5)
Affinity DataIC50: 64.1nMAssay Description:The KRAS (aa 1-169) G12C, C51S, C80L, C118S with a His-tag was expressed, purified and loaded with GDP in house. All protein and substrate solutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent