BDBM626639 4-(6-cyclopropylimidazo[1,2-a]pyridin-2-yl)-N-(2-fluoro-3-methoxy-6-(1H-tetrazol-1-yl)benzyl)-5,6-dihydro-41-pyrrolo[1,2-b]pyrazole-2-carboxamide ::US11787796, Compound I-2

SMILES COc1ccc(c(CNC(=O)c2cc3C(CCn3n2)c2cn3cc(ccc3n2)C2CC2)c1F)-n1cnnn1

InChI Key InChIKey=AMHLPFIUJQCNDZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 626639   

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM626639(4-(6-cyclopropylimidazo[1,2-a]pyridin-2-yl)-N-(2-f...)
Affinity DataEC50:  5.5nMAssay Description:Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent