BDBM627303 3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(3- hydroxy-3-methylbutan-2- yl)-N-(3-methyl-1,1- dioxidothietan-3-yl)-1H- pyrazolo[4,3-b]pyridine-6- carboxamide (faster eluting in AD-H column, 25% MeOH (0.1% DEA)/CO2)::US11787810, Example 131a::US20240059700, Example 131a

SMILES C[C@@H](n1nc(-c2cc(OC(F)F)ccc2F)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O

InChI Key InChIKey=XCIDJTGPVJBTIA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627303   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627303(3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(3- hydr...)
Affinity DataIC50: 11nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627303(3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(3- hydr...)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent