BDBM627311 (R)-N-(4-cyano-3- (trifluoromethyl)phenyl)-3-((4-ethoxy-3- (1-methyl-7-oxo-3-propyl-6,7-dihydro- 1H-pyrazolo[4,3-d]pyrimidin-5- yl)phenyl)thio)-2-hydroxy-2- methylpropanamide::US11787812, Compound 2

SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(SC[C@](C)(O)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)ccc1OCC

InChI Key InChIKey=SQNLLGGCEYUFMN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 627311   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627311(US11787812, Compound 2 | (R)-N-(4-cyano-3- (triflu...)
Affinity DataIC50: 55nMAssay Description:Enzymes and SubstratesCatalog Enzyme Enzyme Used Assay # Lot # (ng/reaction) SubstratePDE5A1 60050 181008-G 0.2 100 nM FAM-cGMPThe serial dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent