BDBM627323 5-(3-(4-ethoxy-3-(1-methyl-7-oxo-3- propyl-6,7-dihydro-1H-pyrazolo[4,3- d]pyrimidin-5-yl)phenyl)-4,4-dimethyl- 5-oxo-2-thioxoimidazolidin-1-yl)-3- (trifluoromethyl)picolinonitrile::US11787812, Compound 19

SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)N1C(=S)N(C(=O)C1(C)C)c1cnc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=BSNNNCNXIROHSU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627323   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627323(US11787812, Compound 19 | 5-(3-(4-ethoxy-3-(1-meth...)
Affinity DataIC50: 100nMAssay Description:Enzymes and SubstratesCatalog Enzyme Enzyme Used Assay # Lot # (ng/reaction) SubstratePDE5A1 60050 181008-G 0.2 100 nM FAM-cGMPThe serial dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetAndrogen receptor(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627323(US11787812, Compound 19 | 5-(3-(4-ethoxy-3-(1-meth...)
Affinity DataIC50: 200nMAssay Description:Human androgen receptors obtained from human LNCaP cells are used in modified HEPES buffer pH 7.4. A 70 μg (adjusted if necessary) aliquot is in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent