BDBM627329 4-(3-(4-ethoxy-3-(5-methyl-4-oxo-7- propyl-3,4-dihydroimidazo[5,1- f][1,2,4]triazin-2-yl)phenyl)-5-oxo-2- thioxoimidazolidin-1-yl)-2- (trifluoromethyl)benzonitrile::US11787812, Compound 25

SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)N1CC(=O)N(C1=S)c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=VLQDZWGNNPPOOJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 627329   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627329(US11787812, Compound 25 | 4-(3-(4-ethoxy-3-(5-meth...)
Affinity DataIC50: 10nMAssay Description:Enzymes and SubstratesCatalog Enzyme Enzyme Used Assay # Lot # (ng/reaction) SubstratePDE5A1 60050 181008-G 0.2 100 nM FAM-cGMPThe serial dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent