BDBM627332 1-(4-cyano-3-(trifluoromethyl)phenyl)- 3-(4-ethoxy-3-(5-methyl-4-oxo-7- propyl-3,4-dihydroimidazo [5,1-f][1,2,4] triazin-2- yl)phenyl)thiourea::US11787812, Compound 28

SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(NC(=S)Nc2ccc(C#N)c(c2)C(F)(F)F)ccc1OCC

InChI Key InChIKey=CHXHKAYBFMVTEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 627332   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627332(US11787812, Compound 28 | 1-(4-cyano-3-(trifluorom...)
Affinity DataIC50: 10nMAssay Description:Enzymes and SubstratesCatalog Enzyme Enzyme Used Assay # Lot # (ng/reaction) SubstratePDE5A1 60050 181008-G 0.2 100 nM FAM-cGMPThe serial dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent