BDBM627341 4-(3-(4-ethoxy-3-(5-methyl-4-oxo-7- propyl-3,4-dihydroimidazo[5,1- f][1,2,4]triazin-2-yl)phenyl)-4,4- dimethyl-5-oxo-2-thioxoimidazolidin-1- yl)-3-fluoro-2- (trifluoromethyl)benzonitrile::US11787812, Compound 47

SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1F)C(F)(F)F

InChI Key InChIKey=SAXZOZCKPYBYHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627341   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627341(US11787812, Compound 47 | 4-(3-(4-ethoxy-3-(5-meth...)
Affinity DataIC50: 10nMAssay Description:Enzymes and SubstratesCatalog Enzyme Enzyme Used Assay # Lot # (ng/reaction) SubstratePDE5A1 60050 181008-G 0.2 100 nM FAM-cGMPThe serial dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetAndrogen receptor(Human)
Ildong Pharmaceutical

US Patent
LigandPNGBDBM627341(US11787812, Compound 47 | 4-(3-(4-ethoxy-3-(5-meth...)
Affinity DataIC50: 50nMAssay Description:Human androgen receptors obtained from human LNCaP cells are used in modified HEPES buffer pH 7.4. A 70 μg (adjusted if necessary) aliquot is in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent