BDBM628439 US11795173, Example 8

SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c([nH]c(=O)c5c(Cl)cnn45)c3F)CC2)c(F)n1

InChI Key InChIKey=AFVMAFOLQJXDAD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 628439   

LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 0.420nMAssay Description:The solution of recombinant poly(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) (40 ng enzyme/well) and the compounds to be tested were mixed, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 19nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
US Patent

LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 19nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent

TargetProtein cereblon/PARP2(Human)TBA
LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 195nMAssay Description:The solution of recombinant poly(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) (40 ng enzyme/well) and the compounds to be tested were mixed, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 3.00E+4nMAssay Description:A PDE3A fluorescence polarization (FP) assay in a multi-step format was performed using black, round bottom 384-well plates (Corning, 4514). The test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProtein cereblon/PARP2(Human)TBA
LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 1.00E+5nMAssay Description:PARP1 and PARP2 protein were expressed, purified, and diluted in assay buffer containing 50 mM Tris pH 8.0, 0.001% Triton X-100, 10 mM MgCI2, 150 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
US Patent

TargetProtein cereblon/PARP2(Human)TBA
LigandPNGBDBM628439(US11795173, Example 8 | US20250215013, Example 60)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were dissolved in DMSO an Echo550 liquid handler was utilized to make serial dilations in the desired concentration range in Optiplate-384F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
US Patent