BDBM628569 (S)-(3-(1-amino-1,3-dihydrospiro[ indene-2,4'-piperidin]-1'-yl)-6-(3-( 3,4-dimethoxyphenoxy)prop-1-yn-1-y 1)pyrazin-2-yl)methanol::US20230339882, Example A11

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(nc1CO)C#CCOc1ccc2cn[nH]c2c1

InChI Key InChIKey=OMJUISOZQZAYCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628569   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM628569((S)-(3-(1-amino-1,3-dihydrospiro[ indene-2,4'-pipe...)
Affinity DataIC50: 1.5nMAssay Description:SHP2 is allosterically activated by binding of a bis-tyrosyl-phosphorylated peptide to its Src homology 2 (SH2) domain. This later activation step re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent