BDBM628591 US20230339882, Example A67

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(nc1CO)C#CCOc1ccc2[nH]ncc2c1

InChI Key InChIKey=XYJFMDNSSNYYKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628591   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM628591(US20230339882, Example A67)
Affinity DataIC50: 3.10nMAssay Description:SHP2 is allosterically activated by binding of a bis-tyrosyl-phosphorylated peptide to its Src homology 2 (SH2) domain. This later activation step re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent