BDBM628998 1-cyclopropyl-N-{3-fluoro-4-[(2-{[2-(4-methanesulfonylpipedidin-1-yl)pyrimidin-4-yl]amino}pyridin-4-yl)oxy]phenyl}-3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide::US20230339891, Example 112

SMILES CS(=O)(=O)C1CCN(CC1)c1nccc(Nc2cc(Oc3ccc(NC(=O)c4cn(C5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)n1

InChI Key InChIKey=OEZCGAGJZUCOEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 628998   

TargetTyrosine-protein kinase receptor UFO(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM628998(1-cyclopropyl-N-{3-fluoro-4-[(2-{[2-(4-methanesulf...)
Affinity DataIC50: 0.800nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM628998(1-cyclopropyl-N-{3-fluoro-4-[(2-{[2-(4-methanesulf...)
Affinity DataIC50: 4.10nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent