BDBM629005 US20230339891, Example 119

SMILES COC(=O)N1CCN(CC1)c1nc(Nc2cc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)ccc1C#N

InChI Key InChIKey=CRJMKZAXSRYICG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629005   

TargetTyrosine-protein kinase Mer(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM629005(US20230339891, Example 119)
Affinity DataIC50: 1.5nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM629005(US20230339891, Example 119)
Affinity DataIC50: 4.20nMAssay Description:Binding assays contained 1 nM kinase (GST-MERTK 578-872, HIS-AXL 473-End, or GST-TYRO 451-890), 0.2 nM terbium labelled antibody (anti-GST or anti-HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent