BDBM629214 Synthesis of trans-3-(1-(4-fluoro-3-methylphenyl)-5-hydroxy-2-(trifluoromethyl)-1H-indol-3-yl)-1-methylcyclobutane-1-carboxylic acid (139)::US20230339915, Compound 139

SMILES Cc1cc(ccc1F)-n1c(c([C@H]2C[C@@](C)(C2)C(O)=O)c2cc(O)ccc12)C(F)(F)F

InChI Key InChIKey=OQQPALKYCZWOCT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629214   

TargetAlpha-1-antitrypsin(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM629214(US20230339915, Compound 139 | Synthesis of trans-3...)
Affinity DataIC50: 5.00E+3nMAssay Description:Assay Protocol: Pre-Incubation of Z-AAT with Compounds1. 7.5 μL of Z-AAT (20 nM) was incubated with compounds 1-227 in a GCA plate for 1 hour at...More data for this Ligand-Target Pair
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Date in BDB:
12/10/2023
Entry Details
US Patent