BDBM629291 (1S,2S)-N-(5-(1 H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyridin-2-yl)-2-fluorocyclopropane-1-carboxamide. 2 HCl salt::US20230339978, Example 1

SMILES F[C@H]1C[C@H]1C(=O)Nc1cc2cc(ccn2n1)-c1cnc2[nH]ccc2c1

InChI Key InChIKey=SWVWXQFAJXFRCG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 629291   

TargetTyrosine-protein kinase ABL1(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629291((1S,2S)-N-(5-(1 H-pyrrolo[2,3-b]pyridin-5-yl)pyraz...)
Affinity DataIC50: 0.710nMAssay Description:c-Abl kinase activity was measured by Promega s ADP-Glo Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/ l) is incubated with 5 L of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629291((1S,2S)-N-(5-(1 H-pyrrolo[2,3-b]pyridin-5-yl)pyraz...)
Affinity DataIC50: 11nMAssay Description:GST-tagged recombinant human RIPK2(25 ng) is incubated with 5 µL of compounds (0.5% DMSO), 5 µL of MBP (0.5 µg/µl) and 5 µL of ATP (25 µM) in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629291((1S,2S)-N-(5-(1 H-pyrrolo[2,3-b]pyridin-5-yl)pyraz...)
Affinity DataIC50: 28nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the AdaptaTM technology in ThermoFisher Scientific. This experiment was carried out acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
1St Biotherapeutics

US Patent
LigandPNGBDBM629291((1S,2S)-N-(5-(1 H-pyrrolo[2,3-b]pyridin-5-yl)pyraz...)
Affinity DataIC50: 55.7nMAssay Description:The LRRK2 and LRRK2 G2019S kinase assays were performed using the AdaptaTM technology in ThermoFisher Scientific. This experiment was carried out acc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent