BDBM629509 US20230339981, Example 197

SMILES CCC[C@@H]1NCCN2[C@@H]1CCCc1nc(c(F)c3nc(OC[C@@]45CCCN4[C@H](COc4cnc(cn4)C(F)(F)F)CC5)nc2c13)-c1cccc2ccc(F)c(C#C)c12

InChI Key InChIKey=LLWBWLIWZKMPIW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629509   

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629509(US20230339981, Example 197)
Affinity DataIC50: 0.0400nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent