BDBM629592 1-((4R,Z)-32,2,2-trifluoro-4,7-dimethyl-67-oxo-67,68- dihydro-5-aza-6(4,8)-pyrido[2,3-d]pyrimidina-1(4,1)- piperidina-3(1,3)-benzenacyclotridecaphan-9-en-66- yl)cyclopropane-1-carbonitrile::US20230339952, Compound 97

SMILES CC1C/C=C\CCCN2CCC(CC2)C(F)(F)c2cccc(c2F)[C@@H](C)Nc2ncnc3c2cc(C2(C#N)CC2)c(=O)n31

InChI Key InChIKey=CORCGKXDSJJEHD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629592   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 629592BDBM629592(US20230339952, Compound 97 | 1-((4R,Z)-32,2,2-trif...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent