BDBM629593 1-((4R,13S)-32,2,2-trifluoro-4,13-dimethyl-67,8- dioxo- 67,68-dihydro-5,9-diaza-6(4,8)-pyrido[2,3- d]pyrimidina-1(4,1)-piperidina-3(1,3)- benzenacyclotridecaphane-66-yl)cyclopropane-1- carbonitrile::US20230339952, Compound 98

SMILES C[C@H]1Nc2ncnc3c2cc(C2(C#N)CC2)c(=O)n3CC(=O)NCCC[C@H](C)N2CCC(CC2)C(F)(F)c2cccc1c2F

InChI Key InChIKey=UPBMDNXBIDOCMG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629593   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 629593BDBM629593(1-((4R,13S)-32,2,2-trifluoro-4,13-dimethyl-67,8- d...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent