BDBM629597 1-((3R,Z)-42,5,5-trifluoro-12,3-dimethyl-17-oxo-17,18- dihydro-7-oxa-2-aza-1(4,8)-pyrido[2,3-d]pyrimidina- 4(1,3)-benzenacyclotetradecaphan-9-en-16- yl)cyclopropane-1-carbonitrile::US20230339952, Compound 105

SMILES C[C@H]1Nc2nc(C)nc3n(CCCC\C=C/COCC(F)(F)c4cccc1c4F)c(=O)c(cc23)C1(CC1)C#N

InChI Key InChIKey=ZWXDQLDPLSINTM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629597   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629597(1-((3R,Z)-42,5,5-trifluoro-12,3-dimethyl-17-oxo-17...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent