BDBM629600 (6R,Z)-86-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)- 52,4,4-trifluoro-6-methyl-87,88-dihydro-11H-7-aza- 8(4,8)-pyrido[2,3-d]pyrimidina-3(1,4)-piperidina- 1(4,1)-triazola-5(1,3)-benzenacyclododecaphan-87- one::US20230339952, Compound 108

SMILES C[C@H]1Nc2ncnc3n(CCCCn4cc(CN5CCC(CC5)C(F)(F)c5cccc1c5F)nn4)c(=O)c(cc23)C1CCS(=O)(=O)CC1

InChI Key InChIKey=CWKYORFVCGHOSE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629600   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629600((6R,Z)-86-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent