BDBM629601 1-((3R,Z)-42,5,5-trifluoro-12,3-dimethyl-17-oxo-17,18- dihydro-7-oxa-2-aza-1(4,8)-pyrido[2,3-d]pyrimidina- 4(1,3)-benzenacyclopentadecaphan-9-en-16- yl)cyclopropane-1-carbonitrile::US20230339952, Compound 109

SMILES Cc1nc2c3cc(C4(C#N)CC4)c(=O)n(c3n1)CCCCC/C=C\COCC(F)(F)c1cccc(c1F)[C@@H](C)N2

InChI Key InChIKey=JQAMWTNCJYFDQF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629601   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 629601BDBM629601(1-((3R,Z)-42,5,5-trifluoro-12,3-dimethyl-17-oxo-17...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent