BDBM629604 (11S,15R,4R)-66-(1,1-dioxidotetrahydro-2H- thiopyran- 4-yl)-32,2,2-trifluoro-4-methyl-67,68-dihydro-18,5- diaza-6(4,8)-pyrido[2,3-d]pyrimidina-1(3,8)- bicyclo[3.2.1]octana-3(1,3)-benzenacyclotridecaphan- 67-one::US20230339952, Compound 113

SMILES C[C@H]1Nc2ncnc3n(CCCCCCCN4C5CCC4CC(C5)C(F)(F)c4cccc1c4F)c(=O)c(cc23)C1CCS(=O)(=O)CC1

InChI Key InChIKey=NUPDBEAGKQDPKP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 629604   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Kumquat Biosciences

US Patent
LigandPNGBDBM629604((11S,15R,4R)-66-(1,1-dioxidotetrahydro-2H- thiopyr...)
Affinity DataIC50: 100nMAssay Description:The assay buffer can contain 5 mM HEPES pH 7.4, 150 mM NaCl, 10 mM EDTA, 1 mM DTT, 0.05% BSA, 0.0025% (v/v) Igepal and 100 mM KF. A Ras working solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent